Sildenafil works by inhibiting a specific enzyme called phosphodiesterase-5 (PDE5). This enzyme normally breaks down cyclic guanosine monophosphate (cGMP), a molecule crucial for smooth muscle relaxation in the penis.
Increased cGMP Levels and Blood Flow
By blocking PDE5, sildenafil increases cGMP levels. Higher cGMP levels relax the smooth muscles in the blood vessels of the penis, allowing increased blood flow. This engorgement of blood is necessary for achieving and maintaining an erection.
Sexual Stimulation Remains Necessary
It’s vital to understand that sildenafil doesn’t directly cause an erection. Sexual stimulation is still required to trigger the release of nitric oxide, which in turn starts the process leading to increased cGMP and subsequent blood flow. Sildenafil simply enhances this natural process by preventing the breakdown of cGMP.
