Viagra (sildenafil) primarily lowers blood pressure by inhibiting an enzyme called phosphodiesterase-5 (PDE5).
This enzyme usually breaks down cyclic guanosine monophosphate (cGMP), a molecule that relaxes blood vessels. By blocking PDE5, Viagra increases cGMP levels. This leads to vasodilation, widening blood vessels and reducing blood pressure.
- The effect is most pronounced in the pulmonary arteries, explaining its use in treating pulmonary hypertension. Systemic blood pressure reduction is also observed, though usually less significant unless a high dose is used or the patient has underlying cardiovascular conditions.
The magnitude of blood pressure reduction varies depending on several factors:
Dosage: Higher doses generally cause a more significant drop. Individual sensitivity: Some individuals are more susceptible to the blood pressure-lowering effects than others. Concurrent medications: Certain medications, especially nitrates, can interact dangerously with Viagra, leading to a potentially hazardous drop in blood pressure. Underlying health conditions: Patients with pre-existing heart problems or low blood pressure are at higher risk of experiencing adverse effects.
Therefore, it’s crucial to discuss any existing health conditions and medications with your doctor before starting Viagra. This allows for careful monitoring and adjustment of the dosage to minimize the risk of complications.
