Sildenafil-50, like other nitrates, can cause dangerously low blood pressure when combined with certain medications. Avoid taking it with nitrates used to treat angina (chest pain), such as nitroglycerin or isosorbide. This combination can lead to severe hypotension and potentially life-threatening consequences.
Alpha-blockers, commonly prescribed for high blood pressure or enlarged prostate, also interact negatively with sildenafil. Concurrent use may significantly lower blood pressure, resulting in dizziness or fainting. Consult your doctor before combining these medications.
Some antifungal medications, particularly azole antifungals like ketoconazole and itraconazole, can increase sildenafil levels in the blood. This leads to a higher risk of side effects, including prolonged erections (priapism). Inform your doctor about all medications you are taking before starting sildenafil.
Similarly, certain protease inhibitors used to treat HIV, such as ritonavir and saquinavir, can elevate sildenafil blood levels, increasing the risk of adverse effects. Careful monitoring and potentially dose adjustment of sildenafil might be necessary.
The following table summarizes medications to avoid with Sildenafil-50:
| Nitrates | Nitroglycerin, Isosorbide mononitrate, Isosorbide dinitrate | Severe hypotension |
| Alpha-blockers | Terazosin, Doxazosin, Tamsulosin | Significant blood pressure drop |
| Azole Antifungals | Ketoconazole, Itraconazole | Increased sildenafil levels, risk of priapism |
| Protease Inhibitors | Ritonavir, Saquinavir | Increased sildenafil levels, increased side effects |
Always inform your doctor and pharmacist about all medications, supplements, and herbal remedies you are taking. This will help prevent dangerous drug interactions and ensure your safety.
