Losartan potassium/HCTZ can interact negatively with several medications. Always inform your doctor about all medications you are taking, including over-the-counter drugs, supplements, and herbal remedies. This is vital for safe use.
Specifically, be aware of potential problems with:
- NSAIDs (Non-Steroidal Anti-Inflammatory Drugs): NSAIDs like ibuprofen or naproxen can reduce the effectiveness of Losartan/HCTZ in lowering blood pressure. Lithium: Losartan/HCTZ may increase lithium levels in the blood, potentially leading to toxicity. Careful monitoring is required if you’re taking both. Potassium supplements or potassium-sparing diuretics: Combining these with Losartan/HCTZ can cause dangerously high potassium levels (hyperkalemia). Alcohol: Excessive alcohol consumption can further lower blood pressure, potentially leading to dizziness or fainting when combined with this medication.
Contraindications include:
Severe kidney problems: Losartan/HCTZ is usually avoided in individuals with severe kidney impairment. Anuria (absence of urine production): This medication should not be used if you have no urine output. Allergy to sulfa drugs: HCTZ (hydrochlorothiazide) is a sulfa drug; an allergy to sulfa drugs is a contraindication. Severe liver disease: Consult your doctor carefully about the appropriateness of this medication if you have significant liver problems. Pregnancy: Losartan is contraindicated during pregnancy, particularly during the second and third trimesters.
This information is not exhaustive. Consult your physician or pharmacist for complete details on interactions and contraindications before starting or continuing Losartan potassium/HCTZ.
