Azithromycin, even at a 500mg IV dose, can cause side effects. These are usually mild and temporary, but awareness is key.
Gastrointestinal Issues
- Nausea and vomiting are common. Consider taking the medication with food to minimize this. Diarrhea can occur; severe cases require medical attention. Abdominal pain is also possible.
Other Potential Side Effects
- Headache is a frequently reported side effect. Dizziness and fatigue may occur. Less common, but still possible, are allergic reactions (rash, itching, swelling), heart rhythm problems (QT prolongation), and liver problems (elevated liver enzymes).
Promptly report any concerning side effects to your doctor.
Drug Interactions
Azithromycin interacts with certain medications. Consult your doctor or pharmacist about potential conflicts before starting treatment.
Significant Interactions:
Ergotamine and dihydroergotamine: Increased risk of ergotism (peripheral vasoconstriction). Drugs metabolized by CYP3A4: Azithromycin inhibits this enzyme, potentially increasing blood levels of other medications (e. g., warfarin, statins, certain antihistamines). Digoxin: Increased risk of digoxin toxicity. Cisapride and pimozide: Increased risk of serious cardiac arrhythmias.
This information is not exhaustive. Always discuss all your medications with your healthcare provider to avoid harmful interactions.
When to Seek Immediate Medical Attention:
- Severe allergic reaction (anaphylaxis: difficulty breathing, swelling of face/throat). Severe diarrhea. Chest pain or irregular heartbeat. Jaundice (yellowing of skin or eyes).
