Combining ciprofloxacin (Cipro) and prednisone can increase your risk of tendon rupture, particularly in older adults or those with kidney problems. This risk is higher with prolonged use of both medications. Monitor for tendon pain, swelling, or inflammation, and report any such symptoms to your doctor immediately.
Cipro can also lower the effectiveness of prednisone by increasing its metabolism. This means your body processes prednisone faster, potentially reducing its therapeutic effect. Your doctor may need to adjust your prednisone dosage to compensate.
Prednisone, being an immunosuppressant, might reduce your body’s ability to fight off infections. Cipro, an antibiotic, may mask the symptoms of infections. This combination therefore warrants careful monitoring for any signs of infection.
Both drugs can cause gastrointestinal side effects like nausea, vomiting, or diarrhea. Taking them together might exacerbate these effects.
Here’s a summary of potential interactions:
| Increased tendon rupture risk | Cipro + Prednisone increases risk, especially in older adults and those with kidney issues. | Report tendon pain or swelling immediately. |
| Reduced Prednisone Effectiveness | Cipro speeds up prednisone metabolism. | Doctor may adjust prednisone dosage. |
| Increased Infection Risk | Prednisone suppresses immunity; Cipro may mask infection symptoms. | Closely monitor for infection signs. |
| Exacerbated Gastrointestinal Effects | Both drugs can cause GI issues. | Report any severe GI symptoms. |
Always inform your doctor and pharmacist about all medications you are taking, including over-the-counter drugs and supplements, before starting any new treatment. Open communication is key to safe and effective medication management.
