The Occupational Safety and Health Administration (OSHA) doesn’t specifically list finasteride as a hazardous drug in its general industry standard. However, the National Institute for Occupational Safety and Health (NIOSH) recommends handling finasteride with precautions consistent with hazardous drugs due to its potential for reproductive toxicity. This recommendation aligns with guidelines from organizations like the Oncology Nursing Society (ONS).
USP Chapter 800 Guidance
USP Chapter 800 provides comprehensive guidance on handling hazardous drugs in healthcare settings. It emphasizes risk assessment, which is critical for determining appropriate handling procedures for finasteride. USP Chapter 800 details specific requirements for personal protective equipment (PPE), engineering controls (e. g., compounding aseptic isolators), and waste disposal. Facilities should follow these guidelines carefully to minimize occupational exposure.
Specific Recommendations for Finasteride Handling
Based on NIOSH and USP Chapter 800 recommendations, handling finasteride should include the use of closed-system drug-transfer devices (CSTDs), powder containment ventilated enclosures (PCVEs) during preparation, and appropriate PPE, including gloves, gowns, and eye protection. Proper disposal procedures, as outlined in USP Chapter 800, are imperative to prevent environmental contamination and reduce exposure risks.
