Lisinopril hydrochlorothiazide combines two distinct medications to lower blood pressure. Lisinopril acts as an ACE inhibitor, preventing the body from producing angiotensin II, a hormone that narrows blood vessels. This leads to vasodilation, reducing blood pressure.
- Lisinopril’s Action: Blocks the angiotensin-converting enzyme (ACE), thus reducing blood vessel constriction. Result: Lowered peripheral resistance and blood pressure.
Hydrochlorothiazide, a thiazide diuretic, works by increasing the excretion of sodium and water from the body through the kidneys. This reduces blood volume, subsequently lowering blood pressure.
- Hydrochlorothiazide’s Action: Increases sodium and water excretion by the kidneys. Result: Reduced blood volume and blood pressure.
The combined effect of these two mechanisms provides a synergistic approach to blood pressure management. Lisinopril’s vasodilatory action complements hydrochlorothiazide’s diuretic effect, offering a more powerful and often more effective blood pressure reduction than either drug alone. Always consult your doctor for personalized advice and dosage information.
Synergistic Effect: Vasodilation (Lisinopril) combined with reduced blood volume (Hydrochlorothiazide) significantly lowers blood pressure. Individualized Treatment: Dosage and suitability depend on your specific health conditions and response to treatment. Seek professional medical guidance.
